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One Health posits that the health of humans and that of the Earth’s environment and its biota – collectively known as the One Health ‘triad’ – are intimately interconnected. This approach signals a major paradigm shift in how we understand factors that affect our wellness, how we relate to the Earth’s biota and environment, and how this has profound implications for our survival and flourishing. One Health, while firmly grounded in the methods and facts of science, is also necessarily multifaceted and interdisciplinary. In this course, we will study the basic components of the One Health triad, how science informs our understanding of their interconnectedness and unity, and threats that disrupt planetary health. We will understand the role of humanities, economics, politics, and policies in One Health, read about and hear from practitioners of One Health, and ultimately synthesize this understanding to craft an ethical worldview for human flourishing.